
Job Description
The Mission
Thesis is assembling a Manhattan Project for autonomous AI research.
We are building the final AI model: a machine to build all other models. Rather than manually chasing isolated model breakthroughs, the hill-climbing machine automates AI R&D itself. By pointing it at grand challenges, we intend to invent the next Transformer or next AlphaFold breakthrough.
As a Member of Technical Staff, you will build this autonomous AI research system to usher in the golden era of discovery. Practically, this includes working on frontier evolutionary search algorithms, agent loops, parallel GPU infrastructure, and fine-tuning.
What You’ll Work On
- Autonomous AI R&D: Design an end-to-end AI system for automated hypothesis generation and model training.
- Evolutionary Search: Build algorithms that navigate massive combinatorial spaces.
- Massively Parallel Systems: Build the distributed infrastructure required to orchestrate thousands of concurrent GPU experiments.
- AI for Science: Direct Darwin’s search capacity toward frontier biological, chemical, and physical challenges.
Who You Are
We seek exceptional AI researchers and engineers to try the unthinkable and seemingly improbable.
- Research Rigor: Deep foundations in ML. A graduate degree in Machine Learning, CS, Math, Stats, Physics, or related quantitative field, or an equivalent track record, is strongly preferred.
-
Core Expertise in One or More Areas
- Evolutionary Search & RL: Evolutionary algorithms, meta-learning, reinforcement learning, or related methods for automated discovery.
- Systems Architecture: Distributed systems, GPU orchestration, schedulers, and high-throughput machine learning pipelines.
- Applied Science: Machine learning applied to computational biology, materials science, chemistry, physics, or robotics.
- Full-Stack Autonomy: You combine scientific intuition with production engineering, shipping fast, fault-tolerant Python and Rust to test hypotheses at scale.
Interview Process
- Introductory Call (1 hr)
- Coding + ML challenge (1hr 30)
- Paid 1 week trial, in person
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Job Details
- Category
- Mechanical
- Employment Type
- Full Time
- Location
- San Francisco, CA
- Posted
- Last updated
- Jul 24, 2026, 07:40 PM
- Compensation
- $120,000 - $170,000 per year
About Thesis
We are accelerating AI research and development. Our aim is to help researchers uncover the next AlphaFold or build the next Transformer, faster, more systematically, and at scale. We treat discovery not as a matter of luck, but as an intelligent search problem. By giving researchers access to an autonomous AI research lab, Thesis lets you build powerful machine learning models for anything imaginable. Every major breakthrough in AI over the next decade will be made on Thesis.
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