# Systems Safety Engineer Jobs in San Francisco, CA

200 systems safety engineer jobs in San Francisco, CA. Top employers: OpenAI, Astranis, Anthropic, and 5 more. Salaries from $30K–$500K.

200 open roles · page 1 of 14

**Principal Electrical Engineer, Power Systems** at Astro Mechanica
San Francisco | FULL_TIME | USD 250K–290K/yr
[Apply](https://zerogtalent.com/space-jobs/astro-mechanica/principal-electrical-engineer-power-systems-8cf17035-cdc7-4b35-8a23-873a2ea67d7d) | [JD](https://zerogtalent.com/api/agent/job/principal-electrical-engineer-power-systems-8cf17035-cdc7-4b35-8a23-873a2ea67d7d)

**Researcher, Misalignment Monitoring Lead** at OpenAI
San Francisco | FULL_TIME | USD 380K–500K/yr
[Apply](https://zerogtalent.com/ai-jobs/openai/researcher-misalignment-monitoring-lead-c955617d-f465-4f7a-b57c-98284fd14777) | [JD](https://zerogtalent.com/api/agent/job/researcher-misalignment-monitoring-lead-c955617d-f465-4f7a-b57c-98284fd14777)

**Principal Software Engineer, Full Stack — Codex** at OpenAI
San Francisco | FULL_TIME | USD 459K–536K/yr
[Apply](https://zerogtalent.com/ai-jobs/openai/principal-software-engineer-full-stack-codex-74842880-e750-4664-9e2e-83b4c96c5a03) | [JD](https://zerogtalent.com/api/agent/job/principal-software-engineer-full-stack-codex-74842880-e750-4664-9e2e-83b4c96c5a03)

**Fabrication Technician** at Mariana Minerals
San Francisco HQ | FULL_TIME | USD 45–55/hr
[Apply](https://zerogtalent.com/frontier-jobs/mariana-minerals/fabrication-technician-0c1ee5fe-ac09-44f4-be12-f5968de0399d) | [JD](https://zerogtalent.com/api/agent/job/fabrication-technician-0c1ee5fe-ac09-44f4-be12-f5968de0399d)

**Research Scientist / Research Engineer, Search Integrity** at OpenAI
San Francisco | FULL_TIME | USD 380K–850K/yr
[Apply](https://zerogtalent.com/ai-jobs/openai/research-scientist-research-engineer-search-integrity-5ef10e09-2b3f-41de-b77c-829787302101) | [JD](https://zerogtalent.com/api/agent/job/research-scientist-research-engineer-search-integrity-5ef10e09-2b3f-41de-b77c-829787302101)

**Mechanical Engineer, Fluid Systems** at Astro Mechanica
San Francisco | FULL_TIME | USD 135K–170K/yr
[Apply](https://zerogtalent.com/space-jobs/astro-mechanica/mechanical-engineer-fluid-systems-b5812615-f479-4727-ae96-3ea75532419a) | [JD](https://zerogtalent.com/api/agent/job/mechanical-engineer-fluid-systems-b5812615-f479-4727-ae96-3ea75532419a)

**Model Policy Manager, National Security** at OpenAI
San Francisco | FULL_TIME | USD 207K–335K/yr
[Apply](https://zerogtalent.com/ai-jobs/openai/model-policy-manager-national-security-230d7d77-133e-4b87-a7a4-3e8d4e9fdab3) | [JD](https://zerogtalent.com/api/agent/job/model-policy-manager-national-security-230d7d77-133e-4b87-a7a4-3e8d4e9fdab3)

**Engineering Manager, Finance Engineering** at Anthropic
San Francisco, CA | Seattle, WA | FULL_TIME | USD 320K–405K/yr
[Apply](https://zerogtalent.com/ai-jobs/anthropic/engineering-manager-finance-engineering-5457708008) | [JD](https://zerogtalent.com/api/agent/job/engineering-manager-finance-engineering-5457708008)

**Research Communications, Models & Frontier AI** at OpenAI
San Francisco | FULL_TIME | USD 297K–330K/yr
[Apply](https://zerogtalent.com/ai-jobs/openai/research-communications-manager-safety-cec9ba9a-0b2d-4e90-8482-01ccc72234fb) | [JD](https://zerogtalent.com/api/agent/job/research-communications-manager-safety-cec9ba9a-0b2d-4e90-8482-01ccc72234fb)

**Corporate Development, Deal Lead** at Anthropic
San Francisco, CA | FULL_TIME
[Apply](https://zerogtalent.com/ai-jobs/anthropic/corporate-development-deal-lead-5459016008) | [JD](https://zerogtalent.com/api/agent/job/corporate-development-deal-lead-5459016008)

**Senior Test Engineer** at Astro Mechanica
San Francisco | FULL_TIME | USD 150K–225K/yr
[Apply](https://zerogtalent.com/space-jobs/astro-mechanica/senior-test-engineer-5abfea5b-15a5-46c1-afba-1568ef02f27f) | [JD](https://zerogtalent.com/api/agent/job/senior-test-engineer-5abfea5b-15a5-46c1-afba-1568ef02f27f)

**Business Development Lead, Life Sciences** at OpenAI
San Francisco | FULL_TIME | USD 400K–445K/yr
[Apply](https://zerogtalent.com/ai-jobs/openai/business-development-lead-life-sciences-f42d2e1e-8c2d-47cf-bd29-4b459c06ae1a) | [JD](https://zerogtalent.com/api/agent/job/business-development-lead-life-sciences-f42d2e1e-8c2d-47cf-bd29-4b459c06ae1a)

**Principal Software Engineer, Productivity** at OpenAI
San Francisco | FULL_TIME | USD 459K–536K/yr
[Apply](https://zerogtalent.com/ai-jobs/openai/principal-software-engineer-productivity-dd9c7c04-7181-4c65-9c6a-0e04313e3707) | [JD](https://zerogtalent.com/api/agent/job/principal-software-engineer-productivity-dd9c7c04-7181-4c65-9c6a-0e04313e3707)

**Senior Electrical Engineer, Power Systems** at Astro Mechanica
San Francisco | FULL_TIME | USD 175K–230K/yr
[Apply](https://zerogtalent.com/space-jobs/astro-mechanica/senior-electrical-engineer-power-systems-1d881540-ef10-4bbb-b6c4-523d121dc360) | [JD](https://zerogtalent.com/api/agent/job/senior-electrical-engineer-power-systems-1d881540-ef10-4bbb-b6c4-523d121dc360)

**Staff Software Engineer, Finance Engineering** at Anthropic
San Francisco, CA | Seattle, WA | FULL_TIME | USD 320K–405K/yr
[Apply](https://zerogtalent.com/ai-jobs/anthropic/staff-software-engineer-finance-engineering-5457716008) | [JD](https://zerogtalent.com/api/agent/job/staff-software-engineer-finance-engineering-5457716008)

[Next page](https://zerogtalent.com/systems-safety-engineer-jobs-in-san-francisco.md?page=2)

---
*Source: [Zero G Talent](https://zerogtalent.com), the job board for space, defense, AI, robotics and frontier-tech companies.*