# Systems Engineer Missile Defense Jobs in San Francisco, CA 200 systems engineer missile defense jobs in San Francisco, CA. Top employers: OpenAI, Astranis, Anthropic, and 5 more. Salaries from $30K–$500K. 200 open roles · page 1 of 14 **Senior Director, Product Management - Defense and Intelligence** at Planet Labs San Francisco, CA | CONTRACTOR | USD 261K–326K/yr [Apply](https://zerogtalent.com/space-jobs/planet-labs/senior-director-product-management-defense-and-intelligence-8263945) | [JD](https://zerogtalent.com/api/agent/job/senior-director-product-management-defense-and-intelligence-8263945) **Principal Mechanical Design Engineer** at Astro Mechanica San Francisco | FULL_TIME | USD 220K–270K/yr [Apply](https://zerogtalent.com/space-jobs/astro-mechanica/principal-mechanical-design-engineer-96349dee-a130-4a74-b602-8977c5b87f4e) | [JD](https://zerogtalent.com/api/agent/job/principal-mechanical-design-engineer-96349dee-a130-4a74-b602-8977c5b87f4e) **Research Engineer** at Greptile San Francisco | FULL_TIME | USD 180K–280K/yr [Apply](https://zerogtalent.com/ai-jobs/greptile/research-engineer-109457) | [JD](https://zerogtalent.com/api/agent/job/research-engineer-109457) **Sr. Enterprise Security Engineer** at Material Security Remote | Remote | FULL_TIME | USD 220K–240K/yr [Apply](https://zerogtalent.com/frontier-jobs/material-security/sr-corporate-security-engineer-df897fcf-10c5-4da2-83ee-2e0eb9268734) | [JD](https://zerogtalent.com/api/agent/job/sr-corporate-security-engineer-df897fcf-10c5-4da2-83ee-2e0eb9268734) **Senior Generalist Engineer** at Greptile San Francisco | FULL_TIME | USD 200K–250K/yr [Apply](https://zerogtalent.com/ai-jobs/greptile/senior-generalist-engineer-109468) | [JD](https://zerogtalent.com/api/agent/job/senior-generalist-engineer-109468) **Staff Generalist Engineer** at Greptile San Francisco | FULL_TIME | USD 250K–300K/yr [Apply](https://zerogtalent.com/ai-jobs/greptile/staff-generalist-engineer-109469) | [JD](https://zerogtalent.com/api/agent/job/staff-generalist-engineer-109469) **Infrastructure Engineer** at Greptile San Francisco | FULL_TIME | USD 220K–300K/yr [Apply](https://zerogtalent.com/ai-jobs/greptile/infrastructure-engineer-109453) | [JD](https://zerogtalent.com/api/agent/job/infrastructure-engineer-109453) **Product Designer** at Greptile San Francisco | FULL_TIME [Apply](https://zerogtalent.com/ai-jobs/greptile/product-designer-114293) | [JD](https://zerogtalent.com/api/agent/job/product-designer-114293) **Director, National Security Capacity Sales** at Astranis San Francisco, CA | FULL_TIME | USD 150K–225K/yr [Apply](https://zerogtalent.com/space-jobs/astranis/director-national-security-capacity-sales-4721544006) | [JD](https://zerogtalent.com/api/agent/job/director-national-security-capacity-sales-4721544006) **Fabrication Technician** at Mariana Minerals San Francisco HQ | FULL_TIME | USD 45–55/hr [Apply](https://zerogtalent.com/frontier-jobs/mariana-minerals/fabrication-technician-0c1ee5fe-ac09-44f4-be12-f5968de0399d) | [JD](https://zerogtalent.com/api/agent/job/fabrication-technician-0c1ee5fe-ac09-44f4-be12-f5968de0399d) **Principal Engineer Capacity/Compute** at Anthropic San Francisco, CA | FULL_TIME | USD 320K–485K/yr [Apply](https://zerogtalent.com/ai-jobs/anthropic/principal-engineer-capacity-compute-5456039008) | [JD](https://zerogtalent.com/api/agent/job/principal-engineer-capacity-compute-5456039008) **Analytical Systems Specialist / Applications Chemist** at Mariana Minerals San Francisco HQ | FULL_TIME | USD 85K–100K/yr [Apply](https://zerogtalent.com/frontier-jobs/mariana-minerals/analytical-systems-specialist-applications-chemist-261f83b0-8d22-4799-bac5-03396fa519e2) | [JD](https://zerogtalent.com/api/agent/job/analytical-systems-specialist-applications-chemist-261f83b0-8d22-4799-bac5-03396fa519e2) **Chief of Staff, GTM** at Greptile San Francisco | FULL_TIME | USD 195K–250K/yr [Apply](https://zerogtalent.com/ai-jobs/greptile/chief-of-staff-gtm-109452) | [JD](https://zerogtalent.com/api/agent/job/chief-of-staff-gtm-109452) **Head of Enterprise Risk Management** at OpenAI San Francisco | FULL_TIME | USD 216K–295K/yr [Apply](https://zerogtalent.com/ai-jobs/openai/head-of-enterprise-risk-management-db40bc4f-c7fb-47d5-a7cc-918fb8b1f815) | [JD](https://zerogtalent.com/api/agent/job/head-of-enterprise-risk-management-db40bc4f-c7fb-47d5-a7cc-918fb8b1f815) **Senior Product Security Engineer (Applications)** at Astranis San Francisco | FULL_TIME | USD 180K–285K/yr [Apply](https://zerogtalent.com/space-jobs/astranis/senior-product-security-engineer-generalist-4667349006) | [JD](https://zerogtalent.com/api/agent/job/senior-product-security-engineer-generalist-4667349006) [Next page](https://zerogtalent.com/systems-engineer-missile-defense-jobs-in-san-francisco.md?page=2) --- *Source: [Zero G Talent](https://zerogtalent.com), the job board for space, defense, AI, robotics and frontier-tech companies.*