Nucleo
The first Agentic platform for Oncology
About the Company
Nucleo is an AI-first medtech startup building the first agentic platform for oncology CT scans.
Our mission is simple and ambitious: reduce the time from cancer diagnosis to treatment from ~10 weeks to ~10 days by automating the most time-consuming, manual steps in the clinical workflow.
Today, hospitals still rely on radiologists and oncologists to manually extract critical information from CT scans - body composition, sarcopenia, tumor measurements, RECIST classification. This is slow, expensive, and error-prone. We replace these steps with AI agents that read CT scans end-to-end and generate structured, clinically useful outputs in seconds.
We work with top-tier hospitals in the US and Europe (including Stanford, Cedars-Sinai, UCI Health, and Weill Cornell) and are building toward FDA-cleared clinical software used directly in real oncology workflows.
We operate in a high-ownership, early-stage environment focused on shipping reliable AI into real clinical practice.
Founders
Angelica Iacovelli is the CEO and co-founder of Nucleo. Previously, she was a researcher at Stanford University, where she worked on cardiovascular modeling, simulating blood flow dynamics using GNNs, LSTMs, and Transformers. The models are now part of NVIDIA’s scientific libraries. She holds BS+MS in Mathematical Engineering from Politecnico di Milano and completed a research exchange at IIT Madras. In 2025, she was recognized as one of the 11 most influential Italians under 35 in software.
I am a researcher in Applied Mathematics and AI for healthcare by training. I hold degrees from Politecnico di Milano, Italy (BSc) and EPFL, Switzerland (MSc and PhD), and have conducted research at the Stanford School of Medicine during my PhD and as a Postdoc. Before founding Nucleo, I was part of Apple Health AI, where I worked on physics-informed machine learning. I've published papers on computational methods, cardiovascular system modeling, and AI for medical images and optical sensors.
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