# Senior Software Engineer Substrate Jobs in San Francisco, CA 200 senior software engineer substrate jobs in San Francisco, CA. Top employers: OpenAI, Astranis, Anthropic, and 5 more. Salaries from $30K–$500K. 200 open roles · page 1 of 14 **Senior Staff Software Engineer - Agent Marketplace** at Kong San Francisco, California, United States | FULL_TIME | USD 250K–270K/yr [Apply](https://zerogtalent.com/ai-jobs/kong/senior-staff-software-engineer-agent-marketplace-ea7b507b-b249-4cf2-88ea-09fbbaf32acb) | [JD](https://zerogtalent.com/api/agent/job/senior-staff-software-engineer-agent-marketplace-ea7b507b-b249-4cf2-88ea-09fbbaf32acb) **Senior FPGA Engineer** at Astranis San Francisco | FULL_TIME | USD 175K–240K/yr [Apply](https://zerogtalent.com/space-jobs/astranis/senior-fpga-engineer-4017405006) | [JD](https://zerogtalent.com/api/agent/job/senior-fpga-engineer-4017405006) **Senior Software Engineer - Backend** at HappyRobot San Francisco | FULL_TIME | USD 220K–250K/yr [Apply](https://zerogtalent.com/ai-jobs/happyrobot/senior-software-engineer-backend-224e1cd5-4299-483d-a6d6-70e34130ad94) | [JD](https://zerogtalent.com/api/agent/job/senior-software-engineer-backend-224e1cd5-4299-483d-a6d6-70e34130ad94) **Senior Generalist Engineer** at Greptile San Francisco | FULL_TIME | USD 200K–250K/yr [Apply](https://zerogtalent.com/ai-jobs/greptile/senior-generalist-engineer-109468) | [JD](https://zerogtalent.com/api/agent/job/senior-generalist-engineer-109468) **(Staff / Senior Staff) AI Infra Engineer, Inference Infrastructure** at Together AI San Francisco | FULL_TIME | USD 250K–320K/yr [Apply](https://zerogtalent.com/ai-jobs/together-ai/staff-senior-staff-ai-infra-engineer-inference-infrastructure-5266079007) | [JD](https://zerogtalent.com/api/agent/job/staff-senior-staff-ai-infra-engineer-inference-infrastructure-5266079007) **Senior Test Engineer** at Astro Mechanica San Francisco | FULL_TIME | USD 150K–225K/yr [Apply](https://zerogtalent.com/space-jobs/astro-mechanica/senior-test-engineer-5abfea5b-15a5-46c1-afba-1568ef02f27f) | [JD](https://zerogtalent.com/api/agent/job/senior-test-engineer-5abfea5b-15a5-46c1-afba-1568ef02f27f) **Senior Engineering Manager, Backend Platform** at Harvey AI San Francisco | FULL_TIME | USD 272K–355K/yr [Apply](https://zerogtalent.com/ai-jobs/harvey-ai/senior-engineering-manager-bc2cf43d-c37d-4496-b64e-277ba79ad415) | [JD](https://zerogtalent.com/api/agent/job/senior-engineering-manager-bc2cf43d-c37d-4496-b64e-277ba79ad415) **Senior Site Reliability Engineer** at Material Security Remote | Remote | FULL_TIME | USD 213K–229K/yr [Apply](https://zerogtalent.com/frontier-jobs/material-security/senior-site-reliability-engineer-c22081a6-2d51-4030-9b6a-062e8a218cdb) | [JD](https://zerogtalent.com/api/agent/job/senior-site-reliability-engineer-c22081a6-2d51-4030-9b6a-062e8a218cdb) **Senior Software Engineer** at Orthogonal San Francisco, CA | FULL_TIME [Apply](https://zerogtalent.com/frontier-jobs/orthogonal/senior-software-engineer-114623) | [JD](https://zerogtalent.com/api/agent/job/senior-software-engineer-114623) **Software Engineer, Platform (Mid-Senior Level)** at Sprinter Health San Francisco, CA | FULL_TIME | USD 175K–225K/yr [Apply](https://zerogtalent.com/frontier-jobs/sprinter-health/software-engineer-platform-mid-senior-level-6fba4665-ad16-457b-a409-96e41ef98528) | [JD](https://zerogtalent.com/api/agent/job/software-engineer-platform-mid-senior-level-6fba4665-ad16-457b-a409-96e41ef98528) **Senior Front End Engineer** at Tempo San Francisco, CA | FULL_TIME [Apply](https://zerogtalent.com/ai-jobs/tempo-fit/senior-front-end-engineer-16199) | [JD](https://zerogtalent.com/api/agent/job/senior-front-end-engineer-16199) **Senior Software Engineer, Product** at Decagon San Francisco | FULL_TIME | USD 200K–400K/yr [Apply](https://zerogtalent.com/ai-jobs/decagon/senior-software-engineer-product-d6636cf6-7750-424a-90a3-7a79ac0c35ca) | [JD](https://zerogtalent.com/api/agent/job/senior-software-engineer-product-d6636cf6-7750-424a-90a3-7a79ac0c35ca) **Staff Technical Product Manager, Evals** at Hercules San Francisco | FULL_TIME | USD 200K–350K/yr [Apply](https://zerogtalent.com/ai-jobs/hercules/staff-technical-product-manager-evals-c033d2e9-7261-46cf-a284-7d9a980133f2) | [JD](https://zerogtalent.com/api/agent/job/staff-technical-product-manager-evals-c033d2e9-7261-46cf-a284-7d9a980133f2) **Senior Software Engineer** at Fuse AI San Francisco, CA, US / Remote (IN; BR; AR) | FULL_TIME | USD 30K–160K/yr [Apply](https://zerogtalent.com/frontier-jobs/fuse-ai/senior-software-engineer-75354) | [JD](https://zerogtalent.com/api/agent/job/senior-software-engineer-75354) **Principal Software Engineer, Full Stack — Codex** at OpenAI San Francisco | FULL_TIME | USD 459K–536K/yr [Apply](https://zerogtalent.com/ai-jobs/openai/principal-software-engineer-full-stack-codex-74842880-e750-4664-9e2e-83b4c96c5a03) | [JD](https://zerogtalent.com/api/agent/job/principal-software-engineer-full-stack-codex-74842880-e750-4664-9e2e-83b4c96c5a03) [Next page](https://zerogtalent.com/senior-software-engineer-substrate-jobs-in-san-francisco.md?page=2) --- *Source: [Zero G Talent](https://zerogtalent.com), the job board for space, defense, AI, robotics and frontier-tech companies.*