Scientist I, Immune Evasion

The Role

Scientist I, Immune Evasion. Advancing Dyno’s immune evasion capabilities by developing and executing innovative assay strategies that enable the discovery and clinical readiness of next-generation capsids.

Job Type: Full Time, onsite

Location: Watertown, MA

How You Will Contribute

As a Scientist I, you will independently lead and evolve Dyno’s high-throughput immune evasion assay platform, driving antibody evasion studies that support CNS and Muscle capsid discovery programs and partnering cross-functionally to shape experimental strategy and address technical gaps. You will also help expand the team’s immune evasion capabilities beyond pre-existing antibodies to emerging clinical readiness challenges, including re-dosing, T-cell responses, complement activation, and innate immunity.

At Dyno, every role is mission-driven. Whether in science, engineering, operations, or business, each AAViator contributes to solving some of the most complex challenges in genetic medicine.

Responsibilities:

• Independently execute and support high-throughput immune evasion (IE) assays, including antibody neutralization and total antibody immunoprecipitation (tAb IP) workflows, to ensure uninterrupted support for CNS and Muscle capsid discovery programs.
• Own the day-to-day operation, optimization, and troubleshooting of immune evasion assay platforms, iteratively refining workflows and developing new assay formats in response to evolving program needs and emerging data.
• Analyze, interpret, and communicate immune evasion screening data to cross-functional stakeholders, helping inform capsid selection and discovery strategy.
• Contribute to the expansion of Dyno’s immune evasion capabilities beyond antibody neutralization by reviewing literature, proposing experimental approaches, and conducting feasibility studies related to re-dosing, T-cell responses, complement activation, and innate immunity.
• Partner closely with Immune Evasion, CNS, Muscle, and in vivo teams to identify technical gaps, improve assay throughput and robustness, and accelerate progress toward clinically ready capsids.
• Support the long-term development of internal immune evasion discovery capabilities, including high-throughput library cloning and production workflows, to increase team self-sufficiency and create additional bandwidth for receptor-targeted capsid discovery efforts.

Basic qualifications

• Ph.D. (or equivalent experience) in Immunology, Cell/Molecular Biology, or a closely related discipline, with deep understanding of immune mechanisms relevant to gene therapy (e.g., humoral immunity, antigen presentation, immune cell activation).
• Hands-on experience with immunological assays (e.g., immunoprecipitation, ELISA, neutralization, ELISPOT assays) and molecular biology techniques (qPCR, flow cytometry, NGS library prep, NGS-based experimental design).
• Prior experience with antibody biology and/or adaptive immune responses (e.g., B-cell/T-cell biology, serology, neutralization mechanisms). This is directly relevant to the team’s core mandate.
• Strong experimental design skills and the ability to independently troubleshoot complex, multi-step assay workflows.
• Ability to critically evaluate scientific literature and translate findings into actionable experimental hypotheses.
• Foundational knowledge of statistical methods for data analysis and hypothesis testing.
• Effective scientific communicator—able to present results clearly to both technical and cross-functional audiences.

Preferred qualifications

• Familiarity with in vivo models of immune response or experience interpreting in vivo immunogenicity data in the context of gene therapy or biologics.
• Prior experience designing and working with high-throughput libraries (DNA/molecular) or large-scale screening workflows.
• Working knowledge of Python or R for data analysis; comfort with large datasets from NGS or high-throughput screening.
• Exposure to AAV biology, gene therapy, or viral vector engineering.

The Company

At Dyno Therapeutics, we are a high-energy, high-impact team on a mission to build high-performance genetic technologies that transform patient lives. Our team unites world-class molecular biologists, protein engineers, software developers, data scientists, and machine learning experts—all working together at the intersection of AI and genetic medicine.

Our culture is defined by three core values that guide everything we do:

• One Mission: Everything we do is for the mission. We are a cohesive and motivated team, thinking ahead and supporting one another to overcome challenges.
• Proactive Responsibility: We take action, inject energy into our work, and hold ourselves accountable for delivering results.
• Reaching for Excellence: We constantly strive for excellence, fueled by curiosity, adaptability, and the courage to speak hard truths in pursuit of success.

These values are more than words—they drive our actions and decisions. Our greatest strength isn’t technology—it’s our work ethic. More than just technologists, we’re a team of relentlessly resourceful problem-solvers: with an unshakable drive we generate breakthroughs at the intersection of AI and genetic medicine.

🚀 What You’ll Give:

• Bring an unstoppable work ethic, stepping up when things get tough and adapting as priorities shift.
• Embrace challenges as opportunities, finding solutions where none exist and driving innovation forward.
• Operate with urgency, responsibility, and resilience, because this mission demands the best from us.

🎯 What You’ll Get:

• Competitive compensation & equity—your contributions drive results, and we pay accordingly.
• Mission-aligned, high-trust environment—we succeed together, supporting each other through challenges.
• A career-defining experience—work at the forefront of AI-driven genetic medicine, tackling problems that reshape healthcare.

If you’re ready to push boundaries, build the future, and thrive in a fast-moving, high-impact environment—we’d love to hear from you.

At Dyno, we believe in transparent and equitable compensation practices.

Base Salary Range: $123,807.01 – $148,568.41/year

This reflects the typical offer range for this role, based on experience, role scope, and internal equity. Final compensation decisions are made using a consistent leveling framework and consider the candidate’s experience, interview performance, and expected impact.

This role is eligible for:

• Annual performance-based bonus
• Stock options
• Comprehensive medical, dental, and vision coverage
• 401(k) plan
• Flexible paid time off and holidays
• Perks including on-campus gym membership, onsite lunch, commuter support, and company provided laptop

Our compensation ranges are reviewed annually to ensure alignment with market trends and internal equity.

Equal Employment Opportunity (EEO) Statement

We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

Fraud Alert: Please be aware of recruitment scams targeting job seekers. Dyno Therapeutics will never make an offer of employment without conducting a formal interview process, nor will we ask for personal information such as financial details over email. Official communication will only come from an @dynotx.com email address. If you are contacted by someone claiming to represent Dyno Therapeutics from any other domain, please report it as spam and report the communication to us at [email protected].