# Design Lead Jobs in San Francisco, CA 200 design lead jobs in San Francisco, CA. Top employers: OpenAI, Astranis, Anthropic, and 5 more. Salaries from $30K–$500K. 200 open roles · page 1 of 14 **Brand Design Lead** at Descript San Francisco, CA or Remote, US | FULL_TIME | USD 140K–185K/yr [Apply](https://zerogtalent.com/ai-jobs/descript/brand-design-lead-8003605003) | [JD](https://zerogtalent.com/api/agent/job/brand-design-lead-8003605003) **Principal Mechanical Design Engineer** at Astro Mechanica San Francisco | FULL_TIME | USD 220K–270K/yr [Apply](https://zerogtalent.com/space-jobs/astro-mechanica/principal-mechanical-design-engineer-96349dee-a130-4a74-b602-8977c5b87f4e) | [JD](https://zerogtalent.com/api/agent/job/principal-mechanical-design-engineer-96349dee-a130-4a74-b602-8977c5b87f4e) **Integrated Content Programs Lead** at Harvey AI San Francisco | FULL_TIME | USD 164K–225K/yr [Apply](https://zerogtalent.com/ai-jobs/harvey-ai/integrated-content-programs-lead-7b8f7427-4372-47a6-b46c-16ce74caa8cf) | [JD](https://zerogtalent.com/api/agent/job/integrated-content-programs-lead-7b8f7427-4372-47a6-b46c-16ce74caa8cf) **Lead Product Manager, Core** at Sprig San Francisco, CA | FULL_TIME | USD 200K–255K/yr [Apply](https://zerogtalent.com/ai-jobs/sprig/lead-product-manager-core-9dc6661c-86bd-4d51-be37-4496b1edfdd0) | [JD](https://zerogtalent.com/api/agent/job/lead-product-manager-core-9dc6661c-86bd-4d51-be37-4496b1edfdd0) **Service Designer, Support** at OpenAI San Francisco | FULL_TIME | USD 216K–310K/yr [Apply](https://zerogtalent.com/ai-jobs/openai/service-designer-support-98cdff28-940d-48e8-b1d7-a0df38dd16d8) | [JD](https://zerogtalent.com/api/agent/job/service-designer-support-98cdff28-940d-48e8-b1d7-a0df38dd16d8) **Founding Lead Engineer** at Toothy AI San Francisco, CA, US / Chicago, IL, US / Remote (US) | FULL_TIME | USD 100K–200K/yr [Apply](https://zerogtalent.com/ai-jobs/toothy-ai/founding-lead-engineer-74334) | [JD](https://zerogtalent.com/api/agent/job/founding-lead-engineer-74334) **Lead Product Designer, Growth** at Perplexity San Francisco | FULL_TIME | USD 180K–300K/yr [Apply](https://zerogtalent.com/ai-jobs/perplexity/lead-product-designer-growth-74a5eaeb-0a4b-412b-ac3a-ad73403b3fb7) | [JD](https://zerogtalent.com/api/agent/job/lead-product-designer-growth-74a5eaeb-0a4b-412b-ac3a-ad73403b3fb7) **Head Product Designer** at Pump.co San Francisco, California, United States | FULL_TIME [Apply](https://zerogtalent.com/ai-jobs/pumpco/head-product-designer-117768) | [JD](https://zerogtalent.com/api/agent/job/head-product-designer-117768) **Lead Product Designer** at Blink San Francisco, CA, US / San Mateo, CA, US / Redwood City, CA, US / Palo Alto, CA, US / Remote (US) | FULL_TIME | USD 60K–120K/yr [Apply](https://zerogtalent.com/ai-jobs/blink/lead-product-designer-84185) | [JD](https://zerogtalent.com/api/agent/job/lead-product-designer-84185) **Product Design Lead, Growth - Codex** at OpenAI San Francisco | FULL_TIME | USD 287K–423K/yr [Apply](https://zerogtalent.com/ai-jobs/openai/product-design-leadership-growth-bce2bcbd-01e6-4afc-9109-d325483aa47e) | [JD](https://zerogtalent.com/api/agent/job/product-design-leadership-growth-bce2bcbd-01e6-4afc-9109-d325483aa47e) **Founding Engineer** at Gauge San Francisco, CA, US | FULL_TIME | USD 170K–220K/yr [Apply](https://zerogtalent.com/ai-jobs/gauge/founding-engineer-85973) | [JD](https://zerogtalent.com/api/agent/job/founding-engineer-85973) **Backend Engineer** at Conductor San Francisco, CA, US | FULL_TIME | USD 200K–350K/yr [Apply](https://zerogtalent.com/ai-jobs/conductor/backend-engineer-94130) | [JD](https://zerogtalent.com/api/agent/job/backend-engineer-94130) **Business Development Lead** at hud San Francisco / Singapore / Remote (Asia) / Remote (North America) | FULL_TIME | USD 100K–230K/yr [Apply](https://zerogtalent.com/ai-jobs/hud/business-development-lead-111723) | [JD](https://zerogtalent.com/api/agent/job/business-development-lead-111723) **Founding Growth Lead** at VideoGen San Francisco, CA / Remote (US; GB) | FULL_TIME | USD 175K–225K/yr [Apply](https://zerogtalent.com/ai-jobs/videogen/technical-seo-lead-98091) | [JD](https://zerogtalent.com/api/agent/job/technical-seo-lead-98091) **Founding Product Designer** at FurtherAI San Francisco, CA, US | FULL_TIME | USD 150K–220K/yr [Apply](https://zerogtalent.com/ai-jobs/furtherai/founding-product-designer-80903) | [JD](https://zerogtalent.com/api/agent/job/founding-product-designer-80903) [Next page](https://zerogtalent.com/design-lead-jobs-in-san-francisco.md?page=2) --- *Source: [Zero G Talent](https://zerogtalent.com), the job board for space, defense, AI, robotics and frontier-tech companies.*