# SiPhox Health Prepares At-Home Photonic Diagnostic Hardware as Mail-In Testing Scales

**Author:** Zero G Talent
**Published:** 2026-11-07
**Category:** operations
**Tags:** yc-hiring, silicon photonics, medical devices, biomarkers, hardware engineering, clinical operations

[Read on Zero G Talent](https://zerogtalent.com/blog/siphox-health-prepares-at-home-photonic-diagnostic-hardware-as-mail-in-testing-scales)

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[SiPhox Health](https://zerogtalent.com/frontier-companies/siphox-health) is building diagnostic hardware designed to replace 100-pound laboratory optical instruments with an area of silicon smaller than a postage stamp. Founded in 2020 by former MIT scientists, the Burlington, Massachusetts company applies silicon photonics—the semiconductor manufacturing process developed for telecom and data communications—to blood biomarker testing. The team has raised $32.8 million across seed and Series A rounds from investors including Intel Capital, Khosla Ventures, and Y Combinator.

While working toward regulatory review for its at-home diagnostic hardware, SiPhox operates an active commercial business around mail-in blood biomarker testing. The company's immediate hiring reflects this two-track operation: engineers in Burlington assembling and testing benchtop hardware, while operations and consumer product teams in Boston and remote locations manage logistics, customer escalation, and digital dashboards.

## Miniaturizing Optical Immunoassays on Silicon Wafers

Standard clinical blood tests rely on optical immunoassay tools housed in central laboratories to measure proteins and hormones. Rather than manufacturing specialized low-cost paper test strips, SiPhox manufactures disposable sensor chips on standard 12-inch silicon wafers in commercial semiconductor foundries. This manufacturing path allows foundries to produce thousands of chips per wafer and up to a billion sensor chips per month, according to the company. Each disposable chip contains a photonic immunoassay sensor array printed with proteins that detect specific targets in blood.

SiPhox is led by Chief Executive Officer [Diedrik Vermeulen](https://zerogtalent.com/people/diedrik-vermeulen) and Co-Founder [Michael Dubrovsky](https://zerogtalent.com/people/michael-dubrovsky). Vermeulen holds a doctorate in photonics from Ghent University, previously worked as director of engineering at Analog Photonics and as an MIT research scientist, and holds 28 patents across optical fiber, free-space, and chip-to-chip coupling. Dubrovsky, who previously led Simply Grid and studied materials science at the Technion and MIT, serves as Chief Product Officer.

Speaking on [The Independent](https://www.independent.co.uk/us/siphox-health-blood-test-b3011690.html) and on [theCUBE](https://www.youtube.com/watch?MuQIsse-8bA), the founders explained that traditional at-home diagnostics struggle with unit economics because complex optical equipment must typically be amortized across thousands of clinical runs. By integrating microfluidics, electronics, and silicon photonics onto a disposable cartridge and companion reader, the company intends to place lab-grade immunoassay capabilities directly in consumer homes.

## Commercial Testing and the Path to At-Home Devices

To build customer volume and refine user experience ahead of hardware clearance, SiPhox deployed an intermediate commercial model: an at-home blood collection kit paired with central laboratory analysis. Users apply the needle-free EasyDraw collection device to their upper arm, collect a sample in roughly five minutes, and mail it via prepaid shipping to a CLIA-certified partner laboratory.

As reported by [Reviewed](https://www.reviewed.com/sponsored-content/features/siphox-health-at-home-biomarker-tests) and [BioSpace](https://www.biospace.com/press-releases/siphox-health-introduces-a-smarter-way-of-health-tracking-from-home), the platform offers panels covering up to 60 biomarkers across cardiovascular fitness, metabolic health, inflammation, thyroid, and hormone levels, starting at $99. In 2025, SiPhox introduced Sai, an AI lab test analyzer that parses lab reports from PDFs and images to give users natural-language biomarker breakdowns.

In June 2026, [Samsung Mobile Press](https://www.samsungmobilepress.com/articles/samsung-panel-discussion-vivatech-2026) detailed Dubrovsky's appearance on an open ecosystem panel at VivaTech alongside executives from Samsung Health and Xealth. Dubrovsky noted that pairing wearable telemetry from consumer hardware with regular biomarker readings offers a more complete health picture than episodic clinical visits.

In an interview on [Healthcare Rap](https://www.youtube.com/watch?v=ooDDr9sxSmU), Dubrovsky outlined the timeline for the dedicated hardware device, which resembles a small countertop machine. The initial deployment aims to serve thyroid patients who require regular biomarker titration to balance medications. The company is preparing data from design-controlled production runs for regulatory submission to the U.S. Food and Drug Administration.

## Hardware and Software Hiring in Massachusetts and Remote

SiPhox lists 10 open positions across engineering, clinical operations, software, and customer experience. The open roles align with the transition from contract laboratory testing to scaling proprietary hardware.

Hardware engineering is focused on-site at the Burlington, Massachusetts headquarters. The [Senior Mechanical Design Engineer](https://zerogtalent.com/frontier-jobs/siphox-health/senior-mechanical-design-engineer-111653) leads mechanical design for medical device subsystems, with responsibilities for manufacturability at scale and travel to manufacturing sites across the US, Europe, and Asia. Working alongside mechanical and optical engineers on the bench, the [System Integration & Test Engineer](https://zerogtalent.com/frontier-jobs/siphox-health/system-integration-test-engineer-111719) uses benchtop tools and Python scripts to assemble, test, and troubleshoot the home testing hardware.

Operational oversight bridges the Burlington lab and remote support teams. The [Manager, Clinical & Product Operations](https://zerogtalent.com/frontier-jobs/siphox-health/manager-clinical-product-operations-117132) reports to the Director of Clinical Operations in Burlington, writing audit-ready standard operating procedures, handling HIPAA compliance, and tracking complaints for both mail-in kits and upcoming hardware. In Boston, the [Wartime Operations and Product Lead](https://zerogtalent.com/frontier-jobs/siphox-health/wartime-operations-lead-100104) manages physical test kit sourcing, freight logistics, and partner laboratory turnaround times.

Product and customer lifecycle roles are divided between Boston and remote posts. The [Product Manager, Mail-In Blood Testing](https://zerogtalent.com/frontier-jobs/siphox-health/product-manager-mail-in-blood-testing-104395) in Boston manages kit design and digital portal metrics, including laboratory redraw rates. The [Head of Consumer Experience; Home blood testing](https://zerogtalent.com/frontier-jobs/siphox-health/head-of-consumer-experience-home-blood-testing-109475) oversees retention and onboarding workflows. Software infrastructure is guided by the remote [Full-Stack Software Development Lead](https://zerogtalent.com/frontier-jobs/siphox-health/full-stack-software-development-lead-100105), who architects distributed data pipelines on AWS for financial and operational reporting.

## Open Positions at SiPhox Health

| Role | Location | Work Mode | Salary |
| --- | --- | --- | --- |
| [Manager, Clinical & Product Operations](https://zerogtalent.com/frontier-jobs/siphox-health/manager-clinical-product-operations-117132) | Burlington, MA | Onsite | $80,000 – $110,000 |
| [Senior Customer Support Specialist and Trainer](https://zerogtalent.com/frontier-jobs/siphox-health/senior-customer-support-specialist-and-trainer-117102) | Burlington, MA / Remote | Remote | $55,000 – $70,000 |
| [Customer Support Lead](https://zerogtalent.com/frontier-jobs/siphox-health/customer-support-lead-117042) | Burlington, MA, US / Remote | Remote | $70,000 – $90,000 |
| [System Integration & Test Engineer](https://zerogtalent.com/frontier-jobs/siphox-health/system-integration-test-engineer-111719) | Burlington, MA, US | Onsite | $70,000 – $120,000 |
| [Senior Mechanical Design Engineer](https://zerogtalent.com/frontier-jobs/siphox-health/senior-mechanical-design-engineer-111653) | Burlington, MA, US | Onsite | $100,000 – $200,000 |
| [Head of Consumer Experience; Home blood testing](https://zerogtalent.com/frontier-jobs/siphox-health/head-of-consumer-experience-home-blood-testing-109475) | Boston, MA, US | Onsite | $150,000 – $200,000 |
| [Product Manager, Mail-In Blood Testing](https://zerogtalent.com/frontier-jobs/siphox-health/product-manager-mail-in-blood-testing-104395) | Boston, MA, US | Onsite | $140,000 – $200,000 |
| [Full-Stack Software Development Lead](https://zerogtalent.com/frontier-jobs/siphox-health/full-stack-software-development-lead-100105) | Remote | Remote | $80,000 – $120,000 |
| [Wartime Operations and Product Lead](https://zerogtalent.com/frontier-jobs/siphox-health/wartime-operations-lead-100104) | Boston, MA, US | Onsite | $100,000 – $160,000 |
| [Technical Product Manager](https://zerogtalent.com/frontier-jobs/siphox-health/technical-product-manager-91395) | Boston, MA, US | Onsite | $100,000 – $150,000 |

[See all open roles at SiPhox Health](https://zerogtalent.com/frontier-companies/siphox-health)

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*Source: [Zero G Talent](https://zerogtalent.com), the job board for space, defense, AI, robotics and frontier-tech companies.*